Welcome to Animal Health, your reference Website

We belong to the VISAVET Research Centre from the Complutense University of Madrid (UCM). We work in research and teaching on animal infectious diseases.

 
  • Vigiasan: Proyecto de Innovación Empleo de Tecnologías para evaluar el estado de salud, bienestar y productividad en ganado

  • VACDIVA quiere resolver el problema de la Peste Porcina Africana (PPA) en Europa y en los países afectados, desarrollando vacunas seguras y efectivas para cerdos domésticos y jabalíes, tests de diagnóstico y herramientas para estrategias de control y erradicación en Europa
  • Proyecto de Innovación "Empleo de Tecnologías para evaluar el estado de salud, bienestar y productividad en ganado"
  • Somos Laboratorio de Referencia de la Organización Mundial de la Sanidad Animal (OIE) en Peste Porcina Africana (PPA) y Peste Equina Africana PEA.
  • Realizamos el diagnóstico de los principales virus que afectan a las abejas, siendo pioneros en el desarrollo y puesta a punto de nuevas técnicas para su estudio.
  • La investigación epidemiologica de la Peste Porcina Clásica y Africana (PPC y PPA) son dos de nuestras prioridades.

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African Swine Fever African Swine Fever videos African Swine Fever Map
 
Marine Animal Health VACDIVA ASF NIFNAF

Epidemiological and genetic analysis of Cetacean Morbillivirus circulating on the Italian coast between 2018 and 2021

New research article in Frontiers in Veterinary Science journal.

Abstract: Cetacean morbillivirus (CeMV) has caused several outbreaks, unusual mortality events, and interepidemic single-lethal disease episodes in the Mediterranean Sea. Since 2012, a new strain with a northeast (NE) Atlantic origin has been circulating among Mediterranean cetaceans, causing numerous deaths. The objective of this study was to determine the prevalence of CeMV in cetaceans stranded in Italy between 2018 and 2021 and characterize the strain of CeMV circulating. Out of the 354 stranded cetaceans along the Italian coastlines, 113 were CeMV-positive. This prevalence (31.9%) is one of the highest reported without an associated outbreak. All marine sectors along the Italian coastlines, except for the northern Adriatic coast, reported a positive molecular diagnosis of CeMV. In one-third of the CeMV-positive cetaceans submitted to a histological evaluation, a chronic form of the infection (detectable viral antigen, the absence of associated lesions, and concomitant coinfections) was suspected. Tissues from 24 animals were used to characterize the strain, obtaining 57 sequences from phosphoprotein, nucleocapsid, and fusion protein genes, which were submitted to GenBank. Our sequences showed the highest identity with NE-Atlantic strain sequences, and in the phylogenetic study, they clustered together with them. Regarding age and species, most of these individuals were adults (17/24, 70.83%) and striped dolphins (19/24, 79.16%). This study improves our understanding on the NE-Atlantic CeMV strain in the Italian waters, supporting the hypothesis of an endemic circulation of the virus in this area; however, additional studies are necessary to deeply comprehend the epidemiology of this strain in the Mediterranean Sea.

 Open acces article

Vargas-Castro I, Peletto S, Mattioda V, Goria M, Serracca L, Varello K, Sánchez-Vizcaíno JM, Puleio R, Nocera FD, Lucifora G, Acutis P, Casalone C, Grattarola C, Giorda F.

Eco-Sanitary Regionalization of Wild Boar (Sus scrofa) in the Western Palearctic Realm as a Tool for the Stewardship of African Swine Fever

We publish a new research article in the journal Transboundary and Emerging Diseases.

Abstract: African swine fever (ASF) is a viral hemorrhagic disease affecting domestic and wild suids, with catastrophic socioeconomic impact worldwide. In the European scenario, wild boar (Sus scrofa) actively contributes to the maintenance and spread of the disease. In this study, we applied a multivariate clustering method to define ecoregions in the western Palearctic realm based on ecological and sanitary aspects of ASF in wild boar. Beforehand, we performed a principal components analysis for the eight selected variables. An analysis of the countries was carried out in terms of the extent of ecoregions and ASF notifications. After clustering, we identified nine eco-regions that showed important differences based on the used eco-sanitary variables. Several ecoregions stand out in the country and notification analysis for retaining the most ASF cases and being present in their surrounding locations. Here, we developed a cartographical tool to understand patterns in the distribution and spread of ASF in wild boar at the European level, as well as improve prevention, control, surveillance plans, and eradication strategies, especially future vaccination programs once a safe and effective vaccine is available.

 Open access article

Aguilar-Vega C, Muñoz-Pérez C, Sanchez-Vizcaino JM, Martínez-Aviles M & Bosch J.

Qualitative risk assessment of Bluetongue virus entry into the Canary Islands

We have submitted a new research article at  the journal Animals.

Abstract: Bluetongue is a viral ruminant disease transmitted by Culicoides spp. biting midges. In the last decades, it increased its expansion and became endemic in areas where it used to be sporadic ie south of Spain, France or Morocco. However, in spite of its widely dissemination, the virus has not ever been reported in the Canary Islands. The disease could cause severe consequences, that is why the interest of assessing the risk of entry of Bluetongue virus into the Canary Islands. An entry qualitative evaluation was performed following the World Organization of Animal Health guidelines. Firstly, risk pathways were identified from literature review; the risk factors related to the level of risk by pathway were selected and combined to get a risk score for every movement, finally, the risk score per movement were analysed to get the temporal and spatial risk of entry. The windborne route was assessed through the trajectory and deposition Hybrid Single Particle Lagrangian Integrated Trajectory Model. The results indicated that the more relevant vía is infected cattle although the risk is very low; and that BTV8 risk slightly outstand BTV 1 and 4. In addition, the risk is principally concentrated in some areas at the North and East of Gran Canaria and Tenerife Island. Other potential routes of entry were vector coming with ungulates or on wind streams however those resulted to be unlikely routes. This work could be useful to focus surveillance measures for cost-effective early detection and prevention programmes.

Gutierrez I, Sanchez-Vizcaino JM, Aguilar-Vega C y Sanchez-Vizcaino F.

A useful tool for the safe diagnosis and control of the two main pandemics of the XXI century: COVID-19 and African Swine Fever disease

Open access article published in Plos One Journal.

Abstract:
The COVID-19 pandemic and the disease triggered by the African Swine Fever virus are currently two of the main problems regarding public and animal health, respectively. Although vaccination seems to be the ideal tool for controlling these diseases, it has several limitations. Therefore, early detection of the pathogen is critical in order to apply preventive and control measures. Real-time PCR is the main technique used for the detection of both viruses, which requires previous processing of the infectious material. If the potentially infected sample is inactivated at the time of sampling, the diagnosis will be accelerated, impacting positively on the diagnosis and control of the disease. Here, we evaluated the inactivation and preservation properties of a new surfactant liquid for non-invasive and environmental sampling of both viruses. Our results demonstrated that the surfactant liquid effectively inactivates SARS-CoV-2 and African Swine Fever virus in only five minutes, and allows for the preservation of the genetic material for long periods even at high temperatures such as 37°C. Hence, this methodology is a safe and useful tool for recovering SARS-CoV-2 and African Swine Fever virus RNA/DNA from different surfaces and skins, which has significant applied relevance in the surveillance of both diseases.

Barroso-Arevalo S, Diaz-Frutos M, Kosowska A, Perez-Sancho M, Domínguez L & Sanchez-Vizcaino JM.

 Open acces article

Development of an Effective Oral Vaccine Dissemination Strategy against Classical Swine Fever for Wild Boar in Gifu Prefecture, Japan

We publish a new research article in the journal Transboundary and Emerging Diseases.

Abstract: In September 2018, classical swine fever (CSF) reemerged in Japan after more than a quarter of a century. After the first notification on a pig farm, wild boars positive for CSF were found continuously in the surrounding area. Gifu was the first prefecture in Japan to disseminate oral vaccines to wild boars in March 2019, with vaccines spread to approximately 14,000 sites between 2019 and 2020. While these diligent measures seemed to have shown some effectiveness, several vaccine spray sites remained without wild boar emergence. Based on the vaccine dissemination records from these periods, this study conducted a statistical analysis to propose more effective vaccine dissemination sites. First, a generalized linear mixed model was used to identify factors correlated with wild boar emergence. Then, two spatial interpolation methods, inverse distance weighted (IDW) and Kriging, were adopted to create a probability map of wild boar emergence for the entire Gifu Prefecture. The analysis showed a positive correlation between wild boar emergence and the appearance of raccoons, raccoon dogs, and crows as well as road density and wild boar distribution index. In particular, raccoon (OR: 1.83, 95%CI: 1.25–2.68,  < 0.001), raccoon dog (OR: 1.81, 95%CI: 1.25–2.66,  < 0.001), and medium level road density (OR: 1.56, 95%CI: 1.04–2.39,  = 0.04) were strongly correlated with wild boar emergence. The spatial interpolation approach resulted in better prediction accuracy for the Kriging method than for IDW by the root mean square error, but both approaches identified a high wild boar appearance probability area in southeastern Gifu and a low appearance probability area in central Gifu. Here we have demonstrated a tool to effectively disperse oral vaccine to wildlife.

 Open accces article

Ito S,  Bosch J, Aguilar-Vega C, Isoda N, Martinez-Aviles M & Sanchez-Vizcaino JM.