Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses.
ResumenAbstractgrown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.
Barasona JA, Cadenas-Fernández E, Kosowska A, Barroso-Arévalo S, Rivera B, Sánchez R, Porras N, Gallardo C and Sánchez-Vizcaíno JM.
José Manuel Sánchez-Vizcaíno, professor of Animal Health at the Complutense University of Madrid (UCM) and researcher at the Veterinary Health Surveillance Center (VISAVET), and Marisa Arias, director of the Animal Health Research Center (CISA-INIA), have been awarded the VII Isabel Mínguez Tudela Prize for Innovation in Animal Health during the XII Annual Conference of the Vet + i Foundation, held this Thursday, November 25, 2021.
Read the article in the Animal's Health magazine (spanish text)